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Effect of 10-day treatment on various metabolic parameters |
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| Vehicle |
3 mg/kg |
10 mg/kg |
30 mg/kg |
Rosiglitazone |
|
|
|
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| Food Intake (g) |
47.8 ± 2.2 |
48.6 ± 2.3 |
51.1 ± 1.9 |
42.9 ± 1.3 |
50.6 ± 1.2 |
| Body Weight (g) |
39.9 ± 0.7 |
42.9 ± 1.2 |
41.2 ± 1.0 |
43.5 ± 1.3 |
45.0 ± 1.0** |
| Body Weight as percent of initial (%) |
96.4 ± 1.0 |
98.0 ± 0.7 |
98.1 ± 0.5 |
100.4 ± 0.1 |
107.3 ± 1.2** |
| Initial body weight (g) |
41.4 ± 0.8 |
43.8 ± 1.2 |
41.9 ± 0.8 |
43.3 ± 1.3 |
41.9 ± 0.68 |
| Fat Pad weight (g) |
1.60 ± 0.07 |
1.72 ± 0.05 |
1.55 ± 0.04 |
1.50 ± 0.07 |
1.68 ± 0.07 |
| Fat pad/body weight ×100 |
4.02 ± 0.18 |
4.03 ± 0.19 |
3.77 ± 0.14 |
3.54 ± 0.23 |
3.74 ± 0.16 |
| Leptin (ng/ml) |
57.2 ± 0.7 |
68.6 ± 4.5 |
59.4 ± 2.3 |
73.6 ± 3.1* |
83.6 ± 2.9*** |
| Insulin (ng/ml) |
20.8 ± 5.2 |
23.6 ± 4.0 |
13.6 ± 4.6 |
17.7 ± 8.4 |
11.8 ± 2.5 |
| Triglycerides (ng/ml) |
1.90 ± 0.18 |
2.29 ± 0.13 |
2.6 ± 0.46 |
3.03 ± 0.30 |
2.3 ± 0.29 |
| Liver triglycerides (mg/g liver) |
14.7 ± 1.0 |
20.4 ± 3.0 |
15.2 ± 1.0 |
18.5 ± 1.4 |
20.9 ± 2.0 |
| Total cholesterol (mM) |
4.0 ± 0.2 |
3.9 ± 0.1 |
4.0 ± 0.1 |
4.1 ± 0.2 |
5.1 ± 0.3** |
| HDL cholesterol (mM) |
3.1 ± 0.2 |
3.0 ± 0.1 |
3.1 ± 0.1 |
3.2 ± 1.3 |
4.1 ± 0.2** |
| Liver cholesterol (mg/g liver) |
4.0 ± 0.2 |
3.8 ± 0.2 |
4.3 ± 0.2 |
3.6 ± 0.1 |
3.2 ± 0.1* |
|
Data are mean ± SEM, n = 8 per group. *p < 0.05, **p < 0.01 and ***p < 0.001 significantly different from vehicle | |||||
Sundbom et al. BMC Pharmacology 2008 8:3 doi:10.1186/1471-2210-8-3 |
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