Table 3

Concentration of desipramine and desmethyldesipramine (DDMI) in the cerebellum of rats at the end of the hypothermic experiments.
Adult Rats
 Post-natal Day 9–12 Rats
Time
(h)
 Desipramine
(ng/g)
 DDMI
(ng/g)
 Desipramine + DDMI
(ng/g)
 Time
(h)
 Desipramine
(ng/g)
 DDMI
(ng/g)
 Desipramine + DDMI
(ng/g)
Acute Treatment
 Acute Treatment
3
 1880 ± 130
 430 ± 95
 2310
 3
 1500 ± 140
 100 ± 17
 1600
Repeated Treatment
 Repeated Treatment
17
 4010 ± 640
 2710 ± 150
 6720
 18
 3750 ± 190
 530 ± 31
 4280
27
 220 ± 50
 510 ± 79
 730
 28
 2550 ± 480
 440 ± 16
 2540
52
 12 ± 12
 34 ± 34
 46
 67
 82 ± 50
 55 ± 18
 137
100
 ND
 ND
 ND
 100
 18 ± 10
 2 ± 2
 20

Rats that had been treated either acutely or for four days with desipramine (same animals as those in Fig. 4–5) were decapitated under isoflurane anesthesia at the completion of the hypothermic experiment (3 to 4 h after giving brimonidine) and the desipramine concentration ± S.E.M. in the cerebellum was determined. The time given in the table is the time after the last dose of desipramine. Thus the 27 hour data in this table, for example, come from the same animals as the 24 hour data in Fig. 4. The number of rats in each group is given in the legends for Fig. 1–3.

ND: Not determined, but assumed to be essentially 0.

Deupree et al. BMC Pharmacology 2008 8:17   doi:10.1186/1471-2210-8-17