Table 2

Gene sets significantly up-regulated after 7 days of medication (day 7).

Rank
Gene Sets – Up-regulated
Size
Nom P-value
FDR (%)

1
Protein disulfide isomerase activity
26
0.0
1.72
2
Intramolecular oxidoreductase activity, transposing S-S bonds
26
0.0
0.86
3
Peptidyl-asparagine modification
16
0.0
3.2
4
Protein amino acid N-linked glycosylation via asparagine
16
0.0
2.4
5
Intramolecular oxidoreductase activity
36
0.0
2.89
6
Protein localization
37
0.0
11.7
7
Isomerase activity
52
0.0
10.9
8
Peptidyl-amino acid modification
23
0.0
10.79
9
Oligosaccharyl transferase complex
19
0.0
10.66

Gene set enrichment analysis (GSEA) with a false discovery rate (FDR) cut-off of approximately 10%. Nominal P values are also shown, as well as gene set sizes (number of genes in each gene set). No gene sets were significantly down-regulated after 7 days of medication, with a FDR lower than about 10%.

Olsvik et al. BMC Pharmacology 2008 8:16   doi:10.1186/1471-2210-8-16