|
Adult survival statistics for all trials. |
||||||
| Trial |
Concentration (μM) |
Mean lifespan (days) |
Relative survival (%) |
p (Logrank) |
n (failed, censor) |
|
|
|
||||||
| Treated |
Control |
|||||
|
|
||||||
| Resveratrol-trimethylether |
||||||
|
|
||||||
| 1 |
100 |
9.7 |
12.16 |
80% |
0.004 |
61,0 |
| 4 |
20 |
7.72 |
11.26 |
69% |
< 0.001 |
61,0 |
| 4 |
40 |
7.72 |
11.26 |
69% |
< 0.001 |
74,0 |
| 4 |
100 |
7.18 |
11.26 |
64% |
< 0.001 |
70,2 |
| 5 |
5 |
18.83 |
18.49 |
102% |
0.91 |
46,3 |
| 5 |
20 |
16.41 |
18.49 |
89% |
0.055 |
42,3 |
| 5 |
100 |
15.18 |
18.49 |
82% |
0.005 |
37,6 |
| 6 |
20 |
9.02 |
15.32 |
59% |
< 0.0001 |
49,5 |
| 6 |
40 |
7.98 |
15.32 |
52% |
< 0.0001 |
51,0 |
| 6 |
100 |
7.54 |
15.32 |
49% |
< 0.0001 |
52,0 |
|
|
||||||
| 3-OH-5,4'- dimethoxystilbene |
||||||
|
|
||||||
| 1 |
100 |
6.34 |
12.16 |
52% |
< 0.0001 |
53,0 |
| 2 |
20 |
11.05 |
11.05 |
100% |
0.986 |
47,2 |
| 2 |
40 |
10.52 |
11.05 |
95% |
0.234 |
40,1 |
| 6 |
20 |
10.38 |
15.32 |
68% |
< 0.0001 |
56,0 |
| 6 |
40 |
7.68 |
15.32 |
50% |
< 0.0001 |
54,1 |
| 6 |
100 |
6.56 |
15.32 |
43% |
< 0.0001 |
55,3 |
|
|
||||||
| Pterostilbene |
||||||
|
|
||||||
| 1 |
100 |
9.55 |
12.16 |
79% |
0.005 |
69,9 |
| 4 |
20 |
10.43 |
11.26 |
93% |
0.336 |
54,0 |
| 4 |
40 |
10 |
11.26 |
89% |
0.035 |
65,1 |
| 4 |
100 |
8.07 |
11.26 |
72% |
< 0.0001 |
51,1 |
| 6 |
20 |
13.72 |
15.32 |
90% |
0.058 |
55,1 |
| 6 |
40 |
14.41 |
15.32 |
94% |
0.142 |
51,4 |
| 6 |
100 |
10.98 |
15.32 |
72% |
< 0.001 |
51,0 |
|
|
||||||
| Desoxyrhapontigenin |
||||||
|
|
||||||
| 1 |
100 |
10.64 |
12.16 |
88% |
0.12 |
61,1 |
| 3 |
100 |
11.31 |
15.37 |
74% |
< 0.0001 |
36,0 |
| 3 |
200 |
11.61 |
15.37 |
76% |
< 0.0001 |
44,1 |
| 4 |
20 |
10.2 |
11.26 |
91% |
0.12 |
74,0 |
| 4 |
40 |
10.38 |
11.26 |
92% |
0.11 |
71,2 |
| 4 |
100 |
9.44 |
11.26 |
84% |
0.003 |
50,0 |
| 6 |
20 |
14.18 |
15.32 |
93% |
0.494 |
54,3 |
| 6 |
40 |
15.31 |
15.32 |
100% |
0.48 |
59,1 |
| 6 |
100 |
13.63 |
15.32 |
89% |
0.027 |
46,9 |
|
|
||||||
| Pinostilbene |
||||||
|
|
||||||
| 1 |
100 |
13.6 |
12.16 |
112% |
0.062 |
68,1 |
| 2 |
20 |
10.04 |
11.05 |
91% |
0.266 |
55,0 |
| 2 |
40 |
11.53 |
11.05 |
104% |
0.319 |
42,5 |
| 3 |
100 |
16.9 |
15.37 |
110% |
0.448 |
41,0 |
| 3 |
200 |
15.23 |
15.37 |
99% |
0.411 |
42,5 |
| 6 |
20 |
14.24 |
15.32 |
93% |
0.319 |
56,3 |
| 6 |
40 |
17.33 |
15.32 |
113% |
0.085 |
60,0 |
| 6 |
100 |
16.24 |
15.32 |
106% |
0.724 |
51,2 |
|
|
||||||
| Resveratrol |
||||||
|
|
||||||
| 1 |
100 |
12.18 |
12.16 |
100% |
0.867 |
70,3 |
| 2 |
20 |
11.85 |
11.05 |
107% |
0.182 |
48,4 |
| 2 |
40 |
10.53 |
11.05 |
95% |
0.924 |
55,0 |
| 3 |
100 |
16.64 |
15.37 |
108% |
0.435 |
30,4 |
| 3 |
200 |
17 |
15.37 |
111% |
0.337 |
38,0 |
| 6 |
20 |
14.65 |
15.32 |
96% |
0.804 |
54,5 |
| 6 |
40 |
16.17 |
15.32 |
106% |
0.501 |
59,0 |
| 6 |
100 |
17.55 |
15.32 |
115% |
0.055 |
58,0 |
|
|
||||||
| Piceatannol |
||||||
|
|
||||||
| 2 |
20 |
11.72 |
11.05 |
106% |
0.362 |
44,0 |
| 2 |
40 |
11.58 |
11.05 |
105% |
0.5 |
37,9 |
| 3 |
100 |
17.78 |
15.37 |
116% |
0.094 |
55,1 |
| 3 |
200 |
17.5 |
15.37 |
114% |
0.166 |
55,1 |
| 6 |
20 |
13.71 |
15.32 |
89% |
0.231 |
50,1 |
| 6 |
40 |
15.63 |
15.32 |
102% |
0.75 |
50,1 |
| 6 |
100 |
16.6 |
15.32 |
108% |
0.146 |
50,1 |
Wilson et al. BMC Pharmacology 2008 8:15 doi:10.1186/1471-2210-8-15 |
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