Table 1

Effect of Atorvastatin and Pitavastatin on L-Methionine induced changes in day 4 escape latency time (ELT), using Morris Water Maze.
Groups
 Treatment
 Dose (kg/day, p.o.)
 ELT (day 1) in sec
 ELT (day 4) in sec
I
 Control
 10 ml(0.5%w/w CMC)
 81.5 ± 4.5
 20.2 ± 2.2a
II
 L-Methionine
 1.7 g
 93.8 ± 4.2
 49.9 ± 2.4b
III
 Atorvastatin per se
 10 mg
 85.5 ± 4.1
 22.4 ± 3.4
IV
 Pitavastatin per se
 10 mg
 82.3 ± 4.3
 21.3 ± 3.8
V
 L-Methionine + Atorvastatin
 10 mg
 81.9 ± 3.9
 27.0 ± 2.4c
VI
 L-Methionine + Pitavastatin
 10 mg
 82.5 ± 4.4
 27.9 ± 3.6c

Each group (n = 10), represent mean ± SEM.

a = p < 0.01 Day 1 Vs Day 4 ELT in vehicle control.

b = p < 0.05 Vs Day 4 ELT in vehicle control.

c = p < 0.05 Vs Day 4 ELT in L-Methionine treated group.

Koladiya et al. BMC Pharmacology 2008 8:14   doi:10.1186/1471-2210-8-14