|
Summary of screening results |
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| Screen |
Screening criteria |
Fraction passing |
Number passing |
|
|
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| 1 |
Oral clearance, LD50, and all six cytotoxicity models |
0.0036 |
416 |
| 2 |
Oral clearance, LD50, and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models |
0.0043 |
498 |
| 3 |
LD50 and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models |
0.035 |
4,014 |
| 4 |
Oral clearance and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models |
0.017 |
1,981 |
| 5 |
Oral clearance, LD50, and passing in both H460 models |
0.0045 |
520 |
| 6 |
Oral clearance and passing in both H460 models |
0.039 |
4,458 |
| 7 |
LD50 and passing in both H460 models |
0.022 |
2,255 |
| 8 |
Passing both H460 models only |
0.24 |
27,608 |
Boik and Newman BMC Pharmacology 2008 8:12 doi:10.1186/1471-2210-8-12 |
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