Table 4

Summary of screening results

Screen

Screening criteria

Fraction passing

Number passing


1

Oral clearance, LD50, and all six cytotoxicity models

0.0036

416

2

Oral clearance, LD50, and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models

0.0043

498

3

LD50 and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models

0.035

4,014

4

Oral clearance and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models

0.017

1,981

5

Oral clearance, LD50, and passing in both H460 models

0.0045

520

6

Oral clearance and passing in both H460 models

0.039

4,458

7

LD50 and passing in both H460 models

0.022

2,255

8

Passing both H460 models only

0.24

27,608


Boik and Newman BMC Pharmacology 2008 8:12   doi:10.1186/1471-2210-8-12

Open Data