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Effect of CS on brain ChAT activity in rats with β-amyloid peptide-(25–35)-induced amnesia. |
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| Treatment Groups |
ChAT activity, dpm/mg of tissue |
|
|
|
| SH |
6.15 ± 0.21* |
| CTR |
4.52 ± 0.25† |
| CH |
4.84 ± 0.68 |
| CS1 |
5.19 ± 0.35 |
| CS10 |
5.39 ± 0.41 |
| CS25 |
5.72 ± 0.38* |
|
ChAT activity in brain cortex homogenates was assayed by radiometry on the day as indicated in the experimental schedule (Figure 11). SH, sham-operated rats (i.p. saline for 7 days); CTR, β-amyloid peptide-(25–35)-induced rats (i.p. saline for 7 days, control); CH, β-amyloid peptide-(25–35)-induced rats treated i.p. for 7 days with choline chloride in dose of 10 mg/kg; CS1, CS10, and CS25, β-amyloid peptide-(25–35)-induced rats treated i.p. for 7 days with CS in doses of 1, 10, or 25 mg/kg respectively. Each group comprised eight rats. Data represent the ChAT activity means ± SEM expressed as dpm/mg of wet tissue. *P < 0.05 vs. CTR. †P < 0.05 vs. SH. | |
Storozheva et al. BMC Pharmacology 2008 8:1 doi:10.1186/1471-2210-8-1 |
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