Figure 5.

A morphologic study of NSCLC and SCLC tumor damage efficiency using the method of vital staining with Evans blue at 48 h post Ce6-PVP mediated PDT. Strong homogeneous staining was observed in the untreated controls (Fig. 5A, B), whereas in the treated tumor at 3 h drug-light interval (DLI) (Fig 5C, D) and at 6 h DLI (Fig 5E, F). Tissues damage was clearly distinguishable as an unstained area in the the tumor. Drug dose: 2.0 mg/kg; light dose: 150 J/cm²; 125 mW/cm². Each data point is an average of at least 5 animals, Bars = standard error of the mean. *The mean difference is significant at the 0.05 level compared to the NSCLC group.