Table 2 |
||||
|
Potency (EC50) values of endogenous and modified CGRP ligands to generate cAMP in transiently transfected HEK293T-RAMP1 cells (in nM). |
||||
|
Peptide Agonist |
Wild Type |
L24A |
L34A |
L24A,L34A |
|
|
||||
|
CGRP |
1.6 ± 0.1 |
1.5 ± 0.4 |
2.0 ± 0.5 |
1.3 ± 0.2 |
|
CGRP(1–36) |
4300 ± 800 |
3400 ± 700 |
5600 ± 800 |
4200 ± 1900 |
|
CGRP(1–19) |
2100 ± 600 |
2400 ± 200 |
2200 ± 600 |
1600 ± 200 |
|
|
||||
|
Banerjee et al. BMC Pharmacology 2006 6:9 doi:10.1186/1471-2210-6-9 |
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