Table 1

IC50 values for the inhibition by DPAB of the oxidation of selected aldehyde substrates by mouse and human ALDH1A1

IC50 of DPAB (μM)

Substrate

ALDH1A1

Mouse

Human


all-trans Retinal

0.11 ± 0.02

0.13 ± 0.03

Propanal

0.040 ± 0.01

0.14 ± 0.04

Phenylacetaldehyde

0.36 ± 0.04

1.2 ± 0.1


IC50 values are the mean ± average deviation from at least 3 spectrophotometric assays, each performed in triplicate.

Russo et al. BMC Pharmacology 2002 2:4   doi:10.1186/1471-2210-2-4

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