Concentration dependent effects of rasagiline, aminoindan and selegiline in the presence of single stimuli (SS) or theta burst stimuli (TBS) after stimulation of the AMPA glutamate receptor by fluorowillardiine (n = 4 slices +- SEM). Statistically significant attenuation of pop-spike amplitude in comparison to fluorowillardiine-induced increases were obtained in the presence of 1 μM of rasagiline or aminoindan following single stimuli (SS). During theta burst stimulation (TBS) already a concentration of 1 μM of rasagiline or aminoindan became statistically significant. Stars indicate statistical significance of p < 0.05 in comparison to control.
Dimpfel and Hoffmann BMC Pharmacology 2011 11:2 doi:10.1186/1471-2210-11-2