Neuroprotective effects of pramipexole (PPX) enatiomers against H2O2-induced cell death. A) Differentiated SH-SY5Y cells were exposed to different concentrations of S(-) PPX (gray bars) and R(+) PPX (black bars) for 1 h before being exposed to 1 mM H2O2 for 10 min. Cell viability was evaluated 24 h after by MTT assay B) Cells were exposed to 50 μM μM S(-) PPX or R(+) PPX in the presence or absence of 10 μM haloperidol (H) or 10 μM (-) sulpiride (S). Data represent means ± SEM of at least three different experiments and are from three separate cell preparations. *, p < 0.01 vs H2O2 alone values.
Ferrari-Toninelli et al. BMC Pharmacology 2010 10:2 doi:10.1186/1471-2210-10-2