Histopathological changes in kidney after administration of paracetamol (H&E staining). Photomicrographs of kidney tissue sections after administration of vehicle or paracetamol. A: (100x) saline group showing normal orientation of nephrons with adequate glomeruli and well spaced tubules. B: Photomicrograph (200x) showing areas of red blood cells extravasating into the interstitium and amidst the spaces between the tubules. C: photomicrograph (400x) showing congested vasculature (arrow) in the juxtaglomerular spaces. D: photomicrograph (200x) where dilated spaces filled with accumulated blood cells, suggesting focal haemorrhages can be observed.
Lim et al. BMC Pharmacology 2010 10:14 doi:10.1186/1471-2210-10-14