|
Effects of control, T. avellanedae aqueous extract (AE, 200 and 400 mg/Kg), and indomethacin (10 mg/Kg) at the rat paw edema induced by carrageenan 1%. The paw volume was measured four times with 1 h intervals between them. It is shown these intervals and the inhibition percentages for each interval. |
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| Average ± SE (mL) |
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|
|
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| Treatment |
Dose |
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| 1 h |
% |
2 h |
% |
3 h |
% |
4 h |
% |
||
| (p.o.) |
(mg/Kg) |
||||||||
|
|
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| Control |
- |
1.33 ± 0.06 |
- |
1.60 ± 0.14 |
- |
1.69 ± 0.12 |
- |
1.7 ± 0.12 |
- |
| Indomethacin |
10 |
0.82 ± 0.02a |
38.6 |
0.88 ± 0.02a |
45.0 |
0.97 ± 0.06a |
42.5 |
1.0 ± 0.07a |
41.3 |
| AE |
200 |
1.13 ± 0.06a |
15.6 |
1.33 ± 0.06a |
16.7 |
1.47 ± 0.05a |
12.7 |
1.46 ± 0.05a |
14.0 |
| AE |
400 |
1.2 ± 0.04 |
9.8 |
1.5 ± 0.07 |
6.7 |
1.65 ± 0.08 |
2.3 |
1.61 ± 0.08 |
5.4 |
|
%, edema inhibition percentage (n = 8/group). SE, average standard error. ap < 0.05 compared to control (Anova, followed by Tukey). | |||||||||
de Miranda et al. BMC Pharmacology 2001 1:6 doi:10.1186/1471-2210-1-6 |
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