Table 3

Effects of cumulative doses of risperidone on urodynamic and EMG parameters in anesthetized rats. Values are Mean ± S.E.M.

Urodynamic parameters

EUS EMG parameters

Dose

BC (ml)

MV (ml)

RV (%)

PT

PP

CT (sec)

ET (sec)

HFO

Phase 1

Phase 2

Phase 3

Burst

(mg/kg)

(mm Hg)

(mm Hg)

(mm Hg)

(%)

(%)

(%)

Amp.

(%)

Control

0.35

0.27

21

2.4

11.5

18.5

3.6

1.6

100

100

100

100

(±0.097)

(±0.072)

(±5.6)

(±0.62)

(±0.95)

(±1.43)

(±0.83)

(±0.19)

0.01

0.38

0.17

47^**

2.8

11.7

19.3

2.7

1.3

100

76

91 (±8.4)

105

(±0.080)

(±0.033)

(±9.2)

(±0.72)

(±1.0)

(±1.97)

(±0.49)

(±0.12)

(±11.5)

(±14.7)

(±3.4)

0.1

0.38

0.10^*

70^**

3.4

11.7

19.4

1.5^**

1.0^*

84

50^*

78^*

80

(±0.055)

(±0.019)

(±7.8)

(±0.44)

(±0.82)

(±1.94)

(±0.34)

(±0.22)

(±11.7)

(±12.3)

(±10.1)

(±19.6)

1

0.40

0.12^**

67^**

5.0^*

12.4

18.6

1.4^**

0.9^**

74

47^*

68^**

76

(±0.060)

(±0.016)

(±5.8)

(±1.02)

(±1.16)

(±2.6)

(±0.35)

(±0.18)

(±13.2)

(±12.7)

(±8.0)

(±14.0)

10

0.54

0.19

60^**

5.8^**

13.7^**

17.2

2.2^*

1.1^*

81

71 (±22)

73^**

84

(±0.080)

(±0.036)

(±7.7)

(±1.02)

(±1.34)

(±0.96)

(±0.46)

(±0.22)

(±15.2)

(±9.0)

(±14.6)

^*

^* p < 0.05; ^** p < 0.01

Vera et al. BMC Pharmacology 2001 1:4   doi:10.1186/1471-2210-1-4