Proposed model for the regulatory roles played by Hsp90 in AD progression. Hsp90 can promote AD by facilitating the activities of protein kinases that cause the pathological features of AD. LTP, long-term potentiation; CTF, carboxyl-terminal fragment – cleavage product of APP (amyloid precursor protein); MT, microtubule.
Luo et al. BMC Neuroscience 2008 9(Suppl 2):S7 doi:10.1186/1471-2202-9-S2-S7