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This article is part of the supplement: Proceedings of the 8th International Conference on Alzheimer's Disease Drug Discovery

Open Access Highly Accessed Review

Therapeutic potential of resveratrol in Alzheimer's disease

Valérie Vingtdeux1, Ute Dreses-Werringloer1, Haitian Zhao1, Peter Davies12 and Philippe Marambaud12*

Author affiliations

1 Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY 11030, USA

2 Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA

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Citation and License

BMC Neuroscience 2008, 9(Suppl 2):S6  doi:10.1186/1471-2202-9-S2-S6

Published: 3 December 2008

Abstract

Several epidemiological studies indicate that moderate consumption of red wine is associated with a lower incidence of dementia and Alzheimer's disease. Red wine is enriched in antioxidant polyphenols with potential neuroprotective activities. Despite scepticism concerning the bioavailability of these polyphenols, in vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases. Furthermore, recent work in cell cultures and animal models has shed light on the molecular mechanisms potentially involved in the beneficial effects of resveratrol intake against the neurodegenerative process in Alzheimer's disease.