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Table 2
Qualitative assessment of pathological progression by region in male 2–26 month-old 3xTg-AD mice.
Antigen	Age (months)

hAPP	2	3	6	9	12	15	18	26
Primary motor cortex	+	+	+	+	+	+	+	+
Amygdala	-	-	+	+	++	++	++	++
Rostral Hippocampus CA1	+	+	+	+	++	++	++	++
Medial Hippocampus CA1	+	+	+	+	++	++	++	++
Caudal Hippocampus CA1/Subiculum	+	+	+	+	++	++	++	++
Entorhinal Cortex	+	+	+	+	++	++	++	++

hAPP/Aβ
Primary motor cortex	+	+	++	++	++	++	+++	+++
Amygdala	+	+	++	++	++	++	+++	+++
Rostral Hippocampus CA1	-	-	+	+	++	++	+++	+++
Medial Hippocampus CA1	-	-	+	+	++	++	+++	+++
Caudal Hippocampus CA1/Subiculum	-	+	+	+	++	+++	+++	+++
Entorhinal Cortex	-	-	+	+	+	+	+++	+++

hAβ 1–42 (Extracellular)
Primary motor cortex	-	-	-	-	-	-	+	++
Amygdala	-	-	-	-	-	-	++	+++
Rostral Hippocampus CA1	-	-	-	-	-	-	+	++
Medial Hippocampus CA1	-	-	-	-	-	-	+	++
Caudal Hippocampus CA1/Subiculum	-	-	-	-	-	+	++	+++
Entorhinal Cortex	-	-	-	-	-	-	+	+++

hAβ 1–42 (Intracellular)
Primary motor cortex	+/-	+/-	+	+	++	++	++	++
Amygdala	+/-	+/-	+	+	++	++	++	++
Rostral Hippocampus CA1	+/-	+	++	++	++	++	++	++
Medial Hippocampus CA1	+	++	++	++	++	++	++	++
Caudal Hippocampus CA1/Subiculum	+	++	++	++	++	++	++	++
Entorhinal Cortex	+/-	+	+	+	+	+	+	+

Human Tau
Primary motor cortex	+/-	+	+	+	+	+	+	+
Amygdala	-	-	+	+	+	+	+	+
Rostral Hippocampus CA1	+/-	+/-	+	+	+	+	+	+
Medial Hippocampus CA1	+/-	+/-	+	+	+	+	++	++
Caudal Hippocampus CA1/Subiculum	+/-	+/-	+	+	+	+	++	++
Entorhinal Cortex	-	-	-	-	-	+/-	+/-	+/-

Phospho-hTau (Thr231)
Primary motor cortex	-	-	-	+	+	+/-	+/-	+
Amygdala	-	-	+	++	++	+	+	++
Rostral Hippocampus CA1	-	-	+/-	+	+	+/-	+/-	+
Medial Hippocampus CA1	-	-	+/-	+	+	+	+/-	++
Caudal Hippocampus CA1/Subiculum	-	-	+	+	+	+	+	+
Entorhinal Cortex	-	-	-	-	-	-	-	+/-

Paired Helical Filaments
Primary motor cortex	-	-	-	-	-	-	-	-
Amygdala	-	-	-	-	-	-	-	-
Rostral Hippocampus CA1	-	-	-	-	-	-	+/-	+
Medial Hippocampus CA1	-	-	-	-	-	-	+/-	+
Caudal Hippocampus CA1/Subiculum	-	-	-	-	-	-	+	+
Entorhinal Cortex	-	-	-	-	-	-	-	+/-

Microglia
Primary motor cortex	+	+	+	+	+	+	++	++
Amygdala	+	+	+	+	+	+	+	++
Rostral Hippocampus CA1	+	+	++	++	++	++	++	++
Medial Hippocampus CA1	+	+	++	++	++	++	++	++
Caudal Hippocampus CA1/Subiculum	+	+	++	++	++	++	+++	+++
Entorhinal Cortex	+	+	++	++	++	++	++	++

Astrocytes
Primary motor cortex	+	+	+	+	+	+	+	+
Amygdala	+/-	+/-	+/-	+/-	+/-	+/-	+/-	+/-
Rostral Hippocampus CA1	+	+	+	+	+	+	+	+
Medial Hippocampus CA1	+	+	+	+	+	+	+	+
Caudal Hippocampus CA1/Subiculum	+	+	+	+	+	+	+	+
Entorhinal Cortex	+	+	+	+	+	+	+	+

Mastrangelo and Bowers BMC Neuroscience 2008 9:81 doi:10.1186/1471-2202-9-81

Table 2