Figure 7.

Anti-apoptotic and anti-oxidative effects of edaravone. Upper column: TUNEL staining revealed that edaravone administration (250 mg/kg) at 30 minutes after 6-OHDA lesion significantly decreased the percentages of TUNEL positive cells in the SNc (b), compared to rats without edaravone-administration (a). Scale bar: 60 μm The graph demonstrates the significant differences (c). Data are shown as the percentages of TUNEL positive cells +S.E. *p < 0.05 vs. the lesion side of edaravone-administered rats and the intact side. Lower column: TH and HEt double staining revealed that edaravone administration (250 mg/kg) at 30 minutes after 6-OHDA lesion significantly decreased the percentages of TH and HEt double positive cells (e), compared to rats without edaravone-administration (d; green: TH, red: HEt; Scale bar: 60 μm). The graph demonstrates the significant differences (f). Data are shown as the percentages of HEt positive cells +S.E. *p < 0.05 vs. the lesion side of edaravone-administered rats and the intact side.

Ji Yuan et al. BMC Neuroscience 2008 9:75   doi:10.1186/1471-2202-9-75
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