Preserved TH-positive fibers in the striatum and neurons in the SNc of rats receiving edaravone-administration. Photomicrographs demonstrate that 100 and 250 mg/kg of edaravone preserved TH immunoreactivity in the striatum and SNc (edaravone-administration at 30 minutes after 6-OHDA lesion, 30 mg/kg: c and i, 100 mg/kg: d and J, 250 mg/kg: e and k, edaravone administration at 24 hours after 6-OHDA lesion, 250 mg/kg: f and l), compared to the untreated 6-OHDA-lesioned rats (b and h). TH staining of the intact side of the striatum and SNc: a and h, TH staining of the striatum: a-f, and the SNc: g-l. Scale bar: 120 μm in a-f, 480 μm in g-l.
Ji Yuan et al. BMC Neuroscience 2008 9:75 doi:10.1186/1471-2202-9-75