Reduced number of HEt-positive cells by edaravone-treatment in vitro. Left column: Edaravone treatment (10-3 M) significantly reduced the number of HEt-positive cells at 10, 20, 30 minutes after edaravone-administration, compared to the untreated 6-OHDA-exposed cells. (untreated 6-OHDA-treated DA neurons at 0 and 30 minutes (a and b); 6-OHDA-treated DA neurons with 10-3 M edaravone at 0 and 30 minutes (c and d). Scale bar: 30 μm. Right column: The graph demonstrates that HEt-positive cells significantly decreased by edaravone-administration. Data are shown as the mean cell number ± S.E. Dotted line: HEt-positive cells without edaravone, Full line: HEt-positive cells with 10-3 M edaravone. *p < 0.05 vs. 6-OHDA-treated DA neurons without edaravone-administration by ANOVA.
Ji Yuan et al. BMC Neuroscience 2008 9:75 doi:10.1186/1471-2202-9-75