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List of regionally enriched genes in 30 brain regions and cell-types of therapeutic interest |
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| Brain Regions/Cell types |
Example Processes/Disease Associations |
Genes |
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| Cortex |
Alzheimer Disease, Amyotropic Lateral Sclerosis, Plasticity |
B3galt2, 3110035E14Rik, Ccl27, Ctgf, Emx1, Fhl2, Klf10, Myl4, Rbp4, Rtn4rl2, Stx1a, Tbr1, Vip, Ddit4l, Dkkl1, Rspo2, Ier5, Igfbp6, Ephb6, Mpped1, Pak7, Satb2, Cplx3, E430002G05Rik |
| Hippocampus |
Alzheimer Disease Adult Neurogenesis, Depression, Plasticity |
Htr1A, Tgfb2, Gria1, Nr3c2 |
| Hippocampus, Ammon's Horn |
Alzheimer Disease Adult Neurogenesis, Depression, Plasticity |
Hunk, Klk8, Gpr161, Arfrp2, C630041L24Rik, Slc9a2, Neurod6, Pkp2, Fibcd1, Sstr4 |
| Hippocampus, Dentate Gyrus |
Alzheimer Disease Adult Neurogenesis, Depression, Plasticity |
Gabrd, Prox1, Dsp, C78409, Lct, Crlf1, Tdo2, A330019N05Rik, Lrrtm4, Htr4, Tspan18 |
| Neurogenic Regions |
Adult Neurogenesis |
Nr2e1, Dcx, Mki67, Vim, Dlx2, Nes, Dlx1, Dscam, Fabp7, Igfbpl1, Lrrn1, Rrm1, Sox2, Thbs4 |
| Striatum |
Huntington Disease, Parkinson Disease, Plasticity in Depression |
Adora2a, Gpr88, Drd1a, Drd2, Gpr6, Rgs9, Adcy5, Crym, Foxp1, Lpl, Pde1b1, Pdyn, Rarb, Rasd2, Tgfa |
| Amygdala |
Huntington Disease, Depression, Plasticity |
Tac1, Cyp26b1, Hap1, Cdh9, Ptprc, Gabra2, Hgf, Pdzrn3, Plxnd1, Wwox, Rasal1, Dock10, Prkcd |
| Amygdala, Basolateral Complex |
Huntington Disease, Depression, Plasticity |
Grp, Nov, Nr2f2 |
| Amygdala, Central Nucleus |
Huntington Disease, Depression, Plasticity |
Atp6v1c2 |
| Thalamus |
Huntington Disease |
Ramp3, Rgs16, Slitrk6, Tnnt1, 1110069I04Rik Amotl1, Rab37, Sh3d19, Grid2ip, Lef1, Plekhg1, Syt9, Tcf7l2, Gm804, Gja7, Socs6, Vangl1 |
| Hypothalamus |
Cancer |
Hcrt, Gpx3, Trh, Fezf1, Agrp, Calcr, Ghrh, Npy, Pmch, Pomc |
| Cerebellum, Granule Cells |
Medulloblastoma, Ataxia, Cerebellar hypoplasia |
Gabra6, Cbln3 |
| Cerebellum, Purkinje Cell Layer |
Spinocerebellar Ataxia, Autism, Plasticity |
Pcp2, Hbegf, Icmt, Atp2a3, Casq2, Gdf10, Grid2, Hes3, Lhx1, Ptprm, A930006D11Rik |
| Basal Nucleus of Meynert |
Acetylcholine System, Alzheimer Disease |
Gal, Ngfr, Tac2, Lhx8, Ecel1, Gbx1, Lancl3, Ntrk1 |
| Substantia Nigra |
Dopamine System, Parkinson Disease |
Ddc, Slc6a3, Ntsr1, Pitx3, Aldh1a1, Chrna6, Chrnb3, Th |
| Raphe Nuclei |
Norepinephrine System, Depression |
Fev, Gchfr, Slc6a4, Slc17a8, Tph2, Maob, Esr2 |
| Locus Coeruleus |
Serotonin System, Depression |
Dbh, Maoa, Slc6a2, Slc18a2 |
| Astroglia |
Alzheimer Disease |
Gfap, S100b, Slc1a2, Plaur, Gcm1, Gcm2, Serpina3n |
| Microglia (activated) |
Alzheimer Disease, Amyotropic Lateral Sclerosis |
Cd68, Aif1, P2rx7, Sulf2 |
| Microglia (constitutive) |
Alzheimer Disease |
Cx3cr1, Itgam |
| Oligodendroglia |
Alzheimer Disease, Multiple Sclerosis |
Olig1, Ugt8a, Cnp, Gjb1, Klk6, Mag, Apod, Enpp2, Fa2h, Mal, Mbp, Mobp, Mog, Olig2, Pllp, Plp1, Sox10, Tmem63a |
| Barrington's Nucleus |
Pain |
Crh, Fgfr1 |
| Brainstem, Pons and Medulla |
Pain |
Slc6a5, Glra1, Pogz, Anxa4, Spp1, Esr1, Pou4f1, Slc4a2, Stac |
| Cortex, Anterior Cingulate |
Pain |
Egr1, Stmn1, Cckbr,Adcy1 |
| Cortex, Somatosensory |
Pain |
Rspo1, Cyp39a1, Cartpt, Col5a1, Rorb, Loc433228, Gnb4 |
| Cortex, Insula |
Pain |
Lxn, Ntng2, Nr4a2, Fezf2, Ttc9b |
| Hypothalamus, Paraventricular Nucleus |
Pain |
Avp, Oxt |
| Subthalamic Nucleus |
Pain |
Pitx2, Lmx1b |
| Blood Brain Barrier |
Drug therapy |
Abcb1a, Cldn5, Ednra, Fcgrt, Hspa12b, Lrp10, Lrp8, Rage, Slc2a1, Slc7a5, Slco1c1, Slc6a12, Slc28a2 |
| GABAergic neurons |
Schizophrenia, Bipolar Disorder |
Vip*, Gpr88‡ |
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*also listed as a cortex-specific gene ‡also listed as a striatum-specific gene | ||
D'Souza et al. BMC Neuroscience 2008 9:66 doi:10.1186/1471-2202-9-66 |
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