The loss of VIP does not impact acquisition of contextual fear conditioning. WT and VIP-deficient mice were trained in the day (ZT 3). Conditioning consisted of two context (CS) and foot shock (US) pairings. Percent freezing following each context-shock pairing was compared between WT (black circles) and VIP-deficient (grey circles) mice (n = 8 per group). There was no difference between the two genotypes in the acquisition of the conditioned fear response.
Chaudhury et al. BMC Neuroscience 2008 9:63 doi:10.1186/1471-2202-9-63