Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

doi:10.1186/1471-2202-9-6

BMC Neuroscience

Volume 9

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Research article

Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

Tomás J Ryan¹^* , Richard D Emes¹^,2^* , Seth GN Grant¹ and Noboru H Komiyama¹

¹Genes to Cognition Program, Wellcome Trust Sanger Institute, Cambridge, UK

²Institute for Science and Technology in Medicine, School of Medicine, Keele University, Staffordshire, UK

author email corresponding author email* Contributed equally

BMC Neuroscience 2008, 9:6doi:10.1186/1471-2202-9-6


Published:	15 January 2008

Additional files

Additional file 1:

Smith-Waterman Alignment of Mouse NR2B C-terminal Exon Nucleotide Sequence against D. melanogaster C-terminal 2857 Nucleotide Intron. Mouse exon sequence named 'NR2B', D. melanogaster intron sequence named 'intron'.

Format: TXT Size: 13KB Download file

Additional file 2:

FoldIndex Comparison of NR2 C-terminal Domain Folding Propensity. Plot of AA sequence of N-terminus (N) to C-terminus (C) of mouse NR2C and NR2D against probability of folding. Green areas are predicted to be intrinsically folded, red areas are predicted to be intrinsically unfolded.

Format: PPT Size: 51KB Download file

This file can be viewed with: Microsoft PowerPoint Viewer

Additional file 3:

PSIPRED Secondary Structure Predictions of Mouse NR2C & NR2D C-terminal Domains. Green barrels represent alpha helices while yellow arrows signify beta sheets. Prediction confidence represented by blue bars.

Format: JPEG Size: 76KB Download file

Additional file 4:

Unrooted Phylogenetic Tree of NR2 Subunits. Human (Hs), mouse (Mm), rat (Rm), zebrafish (Dr), ciona (Ci), Drosophila (Dm), C. elegans (Ce). Bootstrap values are shown at branch points.

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