Figure 4.

Volumetric measurement of neurodegeneration in the striatum and anterior cingulate cortex (ACC). The volumes of the striatum and ACC were calculated for non-enriched (NE), environmentally enriched (EE) and wheel running (RW) groups of wild-type (WT) and HD mice at 9 months of age for the striatum (A and C) and ACC (B and D). The presence of the transgene reduced all these brain volumes, reaching statistical significance for both striatum (P < 0.001) and anterior cingulate cortex (P < 0.05). No effect was seen on the striatum or anterior cingulate cortex by either environmental enrichment or wheel running.