Figure 2.

Wheel running does not delay the onset of a motor co-ordination deficit measured on the accelerating rotarod test. A) On the accelerating rotarod, neither the HD mutation nor wheel running (P = 0.68) had any affect on motor performance of HD mice at 3 months of age. B) The motor deficits which had developed in HD mice at 5 months of age were not affected by wheel running (P = 0.72). NE: non-enriched; RW: running wheel; WT: wild-type; HD: Huntington's disease.