Table 1

Squalestatin alters the trafficking of MoPrP105-132 in neuroblastoma cells. The percentage of MoPrP105-132 that co-localised with cellular markers as shown in untreated neuroblastoma cells and cells treated for 24 hours with 1 μM squalestatin. Values shown are mean percent of peptide that co-localises with markers as shown, ± SD, which was calculated after counting a minimum of 3 cells.

% Co-localisation with MoPrP105-132


Untreated

Squalestatin-treated


CTxB

63% ± 8

5% ± 1

Caveolin-1

73% ± 3

9% ± 3

GM130

41% ± 5

7% ± 2

Grp 78

38% ± 4

3% ± 2

TfR

6% ± 3

68% ± 8

LAMP-1

9% ± 2

40% ± 6


Wilson et al. BMC Neuroscience 2007 8:99   doi:10.1186/1471-2202-8-99

Open Data