Effect of R-flurbiprofen treatment on amyloid-β plaques in Tg2576 mice. Brain sections of representative Control and R-flurbiprofen-treated mice from water maze Experiment 3 (20 months at sacrifice) were stained for Aβ plaques using antibody 33.1.1 (A) and thioflavin (B). In (C), the level of Aβ plaque burden (quantified as % Aβ immunoreactive area) in Control compared to R-flurbiprofen treated-Tg2576 mice from Experiments 2 and 3 are compared. Note the significant reduction in plaque burden in the R-flurbiprofen treated mice from Experiment 3 (*** p < 0.0001).
Kukar et al. BMC Neuroscience 2007 8:54 doi:10.1186/1471-2202-8-54