ELISA quantitation of Aβ levels in Tg2576 from water maze experiments. The levels of detergent soluble (RIPA or SDS) and formic acid soluble Aβ1–40 and Aβ1–42 in R-flurbiprofen treated mice from the three water mazes are plotted as percent control. The mean Aβ levels +/- the standard error from control mice are shown below each graph. The absolute values (pmoles/gram tissue) of formic acid soluble Aβ40 and Aβ42 levels from individual animals are plotted against one another to show the distribution of individual animals from experimental groups. "Preventative 1 and Preventative 2" refers to two different experiments examining the effects of 4 months of administration of R-flurbiprofen to Tg2576 mice. "Therapeutic" refers to 2 weeks administration of R-flurbiprofen.
Kukar et al. BMC Neuroscience 2007 8:54 doi:10.1186/1471-2202-8-54