VP22 enhanced microdystrophin gene expression and distribution in mdx mice. (A) The effect of VP22 was reflected in the level of microdystrophin expression in pAMICDYS (a) and pAVP22-MICDYS (b) injected the left TA muscles. Microdystrophin -positive fibers were detected in both groups, but the number of microdystrophin-positive fibers and the intensity of immunofluorescence were uniformly greater in pAVP22-MICDYS injected TA muscles. Magnification: × 100. (B) Immunostaining analysis microdystrophin expression in mdx mouse TA injected by pAMICDYS (c, f) or pAVP22 -MICDYS (b, e) at 2 weeks (b, c) and 16 weeks (e, f) after injection, the right TA injected by PBS (d). The TA of C57BL/10 (a). Magnification: × 200.
Xiong et al. BMC Neuroscience 2007 8:50 doi:10.1186/1471-2202-8-50