Combinatorial control of transcription and translation on gene expression. Protein production depends on the resultant of transcription and translation events, in which transcriptional activators (TAs) and microRNAs (miRs), respectively, are major effectors. Other important post-transcriptional events are not indicated here, but are reviewed in . Cell context specific combinations of TAs and miRs determine protein A biosynthesis:1) The cell on the left (blue context) has a large amount of transcription activators for gene A promoter and a small amount of miR interacting with the 3' UTR of gene A mRNA. As a result of the strong transcription and the low inhibition of translation, protein A is abundant in this cell. 2) On the contrary, in the cell on the right (orange context) the few TAs and the high numbers of 3' UTR interacting miRs determine a low production of protein A.
Presutti et al. BMC Neuroscience 2006 7(Suppl 1):S5 doi:10.1186/1471-2202-7-S1-S5