Table 2

Human synapsin (Syn) gene family.

Protein

Length (aa)a

Possible Exons

Human-chromosome

Disease

Interactions


Synapsin 1 (Syn1)

705/669/261

16

Xp11.23

ALZ, epilepsy

Rab3, S100A1, Actin, tubulin, CAPON, Syn1, Syn2, Syn3

Synapsin 2 (Syn2)

505/401/301/285

21

3p25.2

schizophrenia

Actin, CAPON, PLCĪ³1, Syn1, Syn2, Syn3

Synapsin 3 (Syn3)

580/579/456/451/236/192/(+ 4)

31

22q12.3

Schizophrenia Bipolar disorder Multiple sclerosis

Actin, CAPON, Syn1, Syn2, Syn3


aVariants listed are alternatively spliced forms. The expression of some of these variants is detected only under extreme stimulation conditions. The expression of some of these variants was not confirmed experimentally. Syns can form homo- and heterocomplexes among their family members.

Brachya et al. BMC Neuroscience 2006 7(Suppl 1):S4   doi:10.1186/1471-2202-7-S1-S4

Open Data