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This article is part of the supplement: Problems and tools in the systems biology of the neuronal cell

Open Access Open Badges Review

Model storage, exchange and integration

Nicolas Le Novère

Author Affiliations

EMBL-EBI, Wellcome-Trust Genome Campus, Hinxton, UK

BMC Neuroscience 2006, 7(Suppl 1):S11  doi:10.1186/1471-2202-7-S1-S11

Published: 30 October 2006


The field of Computational Systems Neurobiology is maturing quickly. If one wants it to fulfil its central role in the new Integrative Neurobiology, the reuse of quantitative models needs to be facilitated. The community has to develop standards and guidelines in order to maximise the diffusion of its scientific production, but also to render it more trustworthy. In the recent years, various projects tackled the problems of the syntax and semantics of quantitative models. More recently the international initiative launched three projects: (1) MIRIAM is a standard to curate and annotate models, in order to facilitate their reuse. (2) The Systems Biology Ontology is a set of controlled vocabularies aimed to be used in conjunction with models, in order to characterise their components. (3) BioModels Database is a resource that allows biologists to store, search and retrieve published mathematical models of biological interests. We expect that those resources, together with the use of formal languages such as SBML, will support the fruitful exchange and reuse of quantitative models.