Table 1 |
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|
Electrophysiological analysis of infected neurons. Electrophysiological characterization of traced nasal, cutaneous, in vitro infected (iv infected), and uninfected (control) TGNs revealed no significant differences. APs: Action potentials |
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|
control TGNs |
iv infected TGNs |
nasal TGNs |
cutaneous TGNs |
control TGNs |
iv infected TGNs |
nasal TGNs |
cutaneous TGNs |
|
|
|
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|
Membrane potential/mV |
Width of AP at 75 % of amplitude/ms |
|||||||
|
n |
111 |
78 |
20 |
17 |
94 |
42 |
14 |
13 |
|
mean |
-56,0 |
-54,3 |
-55,0 |
-54,4 |
2,27 |
2,26 |
1,96 |
2,40 |
|
SD |
8,1 |
10,6 |
9,7 |
6,9 |
0,96 |
1,19 |
0,86 |
0,95 |
|
SEM |
0,8 |
1,2 |
2,2 |
1,7 |
0,10 |
0,18 |
0,23 |
0,26 |
|
range |
38 |
66 |
33 |
23 |
4,60 |
5,40 |
3,00 |
3,40 |
|
Threshold for activation of VGSCs/mV |
Maximal amplitude of APs due to current injection/mV |
|||||||
|
n |
106 |
45 |
12 |
14 |
95 |
42 |
14 |
14 |
|
mean |
-32,9 |
-32,5 |
-33,0 |
-31,5 |
41,3 |
36,8 |
37,9 |
51,3 |
|
SD |
9,6 |
11,1 |
11,3 |
12,2 |
16,3 |
15,3 |
15,3 |
10,3 |
|
SEM |
0,9 |
1,7 |
3,3 |
3,3 |
1,7 |
2,4 |
4,1 |
2,8 |
|
range |
60 |
60 |
40 |
36 |
73 |
69 |
48 |
36,0 |
|
Maximal amplitude (overshoot) of APs/nA |
Ih current (-130 mV)/pA |
|||||||
|
n |
12 |
10 |
16 |
14 |
67 |
14 |
7 |
10 |
|
mean |
-3,80 |
-5,22 |
-3,78 |
-7,2 |
-258 |
-226 |
-327 |
-130 |
|
SD |
1,95 |
2,74 |
2,69 |
3,21 |
221 |
205 |
325 |
109 |
|
SEM |
0,56 |
0,87 |
0,67 |
0,86 |
27 |
55 |
123 |
35 |
|
range |
6,25 |
7,49 |
9,24 |
12,07 |
1066 |
639 |
845 |
363 |
|
Threshold of current injection for eliciting APs/pA |
Amplitude of "sag"/mV |
|||||||
|
n |
95 |
42 |
14 |
n.d. |
11 |
18 |
8 |
3 |
|
mean |
258 |
237 |
213 |
n.d. |
10,1 |
18,6 |
22,6 |
17,0 |
|
SD |
246 |
201 |
202 |
n.d. |
6,2 |
10,5 |
15,6 |
8,0 |
|
SEM |
25 |
31 |
54 |
n.d. |
1,9 |
2,5 |
5,5 |
4,6 |
|
range |
990 |
800 |
770 |
n.d. |
17 |
37 |
44 |
16,0 |
|
Membrane potential due to current injection eliciting APs/mV |
Threshold of current injection for Ih-activation/mV |
|||||||
|
n |
94 |
42 |
14 |
14 |
11 |
18 |
8 |
3 |
|
mean |
-30,1 |
-31,5 |
-34,6 |
-32,9 |
-79,5 |
-83,4 |
-81,9 |
-87,3 |
|
SD |
8,1 |
10,5 |
7,9 |
7,8 |
7,6 |
20,4 |
10,3 |
7,5 |
|
SEM |
0,8 |
1,6 |
2,1 |
2,1 |
2,3 |
4,8 |
3,7 |
4,3 |
|
range |
54 |
46 |
29 |
27 |
26 |
83 |
31 |
15 |
|
|
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|
Damann et al. BMC Neuroscience 2006 7:46 doi:10.1186/1471-2202-7-46 |
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