Figure 10.

Purines induce different TGN responses. (A) Application of ATP (30 μM) revealed three types of inward currents in patch-clamp measurements. Horizontal Bar: 1 s; Vertical bars in from above: 250 pA, 250 pA, 100 pA (B) Current characteristics of nasal (n = 25) and cutaneous (n = 16) TGNs due to purinergic stimulation. (C) Transient responses within the groups 'transient' and 'mixed': black bars; Persistent responses within the groups 'persistent' and 'mixed': grey bars. Both neuronal subpopulations equally revealed the persistent response but cutaneous TGNs showed significantly more transient currents.