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Open Access Highly Accessed Research article

Callosal connections of dorsal versus ventral premotor areas in the macaque monkey: a multiple retrograde tracing study

Driss Boussaoud1*, Judith Tanné-Gariépy1, Thierry Wannier23 and Eric M Rouiller2

Author Affiliations

1 Institut de Neurosciences Cognitives de la Méditerranée, INCM, UMR 6193, CNRS, Université de la Méditerranée, 31 Ch. Joseph Aiguier, 13402 Marseille Cedex 20, France

2 Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland

3 Brain Research Institute, Dept. Neuromorphology, University and ETH Zurich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland

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BMC Neuroscience 2005, 6:67  doi:10.1186/1471-2202-6-67

Published: 25 November 2005

Abstract

Background

The lateral premotor cortex plays a crucial role in visually guided limb movements. It is divided into two main regions, the dorsal (PMd) and ventral (PMv) areas, which are in turn subdivided into functionally and anatomically distinct rostral (PMd-r and PMv-r) and caudal (PMd-c and PMv-c) sub-regions. We analyzed the callosal inputs to these premotor subdivisions following 23 injections of retrograde tracers in eight macaque monkeys. In each monkey, 2–4 distinct tracers were injected in different areas allowing direct comparisons of callosal connectivity in the same brain.

Results

Based on large injections covering the entire extent of the corresponding PM area, we found that each area is strongly connected with its counterpart in the opposite hemisphere. Callosal connectivity with the other premotor areas, the primary motor cortex, prefrontal cortex and somatosensory cortex varied from one area to another. The most extensive callosal inputs terminate in PMd-r and PMd-c, with PMd-r strongly connected with prefrontal cortex. Callosal inputs to PMv-c are more extensive than those to PMv-r, whose connections are restricted to its counterpart area. Quantitative analysis of labelled cells confirms these general findings, and allows an assessment of the relative strength of callosal inputs.

Conclusion

PMd-r and PMv-r receive their strongest callosal inputs from their respective counterpart areas, whereas PMd-c and PMv-c receive strong inputs from heterotopic areas as well (namely from PMd-r and PMv-r, respectively). Finally, PMd-r stands out as the lateral premotor area with the strongest inputs from the prefrontal cortex, and only the PMd-c and PMv-c receive weak callosal inputs from M1.