PROG [M] is partially neuroprotective against synergistic neurotoxicity of HIV proteins with cocaine (Coc). Control conditions of incubation with Locke's Buffer vehicle or the HIV proteins or Coc only produced similar neuronal death. (Left Panel) Significant interaction of the HIV proteins with Coc, as illustrated by the lines diverging from parallel, produced toxic synergism (*p < 0.0044). (Right Panel) PROG provided partial neuroprotection against HIV proteins w/ Coc toxic synergism at all concentrations tested (#p < 0.0025) however, the neuroprotection was not concentration dependent.
Kendall et al. BMC Neuroscience 2005 6:40 doi:10.1186/1471-2202-6-40