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Lamina cribrosa cell and ONH astrocyte responses to oxygen-glucose deprivation. |
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| Lamina cribrosa cells |
ONH astrocytes |
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| Cell Number |
95 % survival at 24 hrs, 85% at 48 hrs |
70 % survival at 24 hrs, 80% at 48 hrs |
| NT Expression |
↑ NGF, ↑ BDNF, ↑ NT-3; ↓ NT-4 |
↑ BDNF, ↑ NT-3; ↓ NGF, ↓ NT-4 |
| Trk Expression |
↑ Trk A; ↓ Trk C, ↓ Trk B |
↓ Trk A, ↓ Trk C, ↓ Trk B.T |
| Phospho-Trk Expression |
↑ 120 kDa isoform (Trk A); ↓ 148 kDa isoform |
↓ all phospho-trk receptors |
| isoform |
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| Secretion of NTs |
↑ NGF; ↓ BDNF |
↑ NGF; ↓ BDNF |
Lambert et al. BMC Neuroscience 2004 5:51 doi:10.1186/1471-2202-5-51 |
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