Cre-mediated recombination in the neocortex and hippocampus of Rosa26 reporter mice, 4 weeks following injection of LV-Cre-EGFP recombinant virus (A-C) or a mixture of AAV-Cre and AAV-GFP recombinant viruses (AAV-Cre/AAV-GFP mixture) (D-F). β-galactosidase activity is apparent in and around the needle track in the neocortex (arrows in A and D), in parts of the CA1, CA2 and terminal portion of the CA3 region of the hippocampus and in the dentate gyrus. Cells in stratum lacunosum-moleculare (arrowheads in A and D), corpus callosum (arrow in B and E) were also observed. Parts of CA1 and CA2 from Fig. 5A and 5D are enlarged in Fig. 5B and 5E and the region of the dentate gyrus from Fig. 5A and 5D is enlarged in Fig. 5C and 5F. Scale bars in A = 200 μm (applies also to D); B = 100 μm (applies also to C, E and F).
Ahmed et al. BMC Neuroscience 2004 5:4 doi:10.1186/1471-2202-5-4