Cre-mediated recombination following injection of LV-Cre-EGFP (A-C) and a mixture of AAV-Cre and AAV-GFP recombinant viruses (AAV-Cre/AAV-GFP mixture) (D-F) into the neocortex and hippocampus of Rosa26 reporter mice. Expression of β-galactosidase, indicating Cre-mediated excision of the loxP flanked stop signal, was detected by the X-gal staining. β-galactosidase activity was prominent in the dentate gyrus of animals at all postinjection intervals (arrows in A-F). Scale bars A= 100 μm (applies also to B-F).
Ahmed et al. BMC Neuroscience 2004 5:4 doi:10.1186/1471-2202-5-4