Enhancement of blood-tumor barrier permeability by Sar-[D-Phe8]des-Arg9BK, a metabolically resistant bradykinin B1 agonist, in a rat C6 glioma model

doi:10.1186/1471-2202-5-38

BMC Neuroscience

Volume 5

Viewing options:

Abstract
Full text
PDF (260KB)

Associated material:

Related literature:

Articles citing this article
on Google Scholar
on ISI Web of Science
on PubMed Central
Other articles by authors
on Google Scholar

Cardoso RC
Lobão-Soares B
Bianchin MM
Carlotti CG
Walz R
Alvarez-Silva M
Trentin AG
Nicolau M

on PubMed

Cardoso RC
Lobão-Soares B
Bianchin MM
Carlotti CG
Walz R
Alvarez-Silva M
Trentin AG
Nicolau M
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Twitter

Research article

Enhancement of blood-tumor barrier permeability by Sar-[D-Phe8]des-Arg9BK, a metabolically resistant bradykinin B1 agonist, in a rat C6 glioma model

Ronie Cleverson Cardoso¹ , Bruno Lobão-Soares²^,3 , Marino Muxfeldt Bianchin³ , Carlos Gilberto Carlotti Jr⁴ , Roger Walz²^,5^,6 , Márcio Alvarez-Silva² , Andréa Gonçalves Trentin³ and Mauro Nicolau¹

¹Departamento de Fisiologia, Universidade Federal de Santa Catarina, Brazil

²Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Brazil

³Departamento de Neurologia, Psiquiatria e Psicologia Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

⁴Departamento de Cirurgia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

⁵Centro de Cirurgia de Epilepsia, Hospital Governador Celso Ramos, Florianópolis, Santa Catarina, Brazil

⁶Centro de Ciências da Saúde, Faculdade de Medicina da Universidade do Vale do Itajaí, UNIVALI, Itajaí, Santa Catarina, Brazil

author email corresponding author email

BMC Neuroscience 2004, 5:38doi:10.1186/1471-2202-5-38


Published:	30 September 2004

Abstract

Background

While it is well known that bradykinin B2 agonists increase plasma protein extravasation (PPE) in brain tumors, the bradykinin B1 agonists tested thus far are unable to produce this effect. Here we examine the effect of the selective B1 agonist bradykinin (BK) Sar-[D-Phe8]des-Arg9BK (SAR), a compound resistant to enzymatic degradation with prolonged activity on PPE in the blood circulation in the C6 rat glioma model.

Results

SAR administration significantly enhanced PPE in C6 rat brain glioma compared to saline or BK (p < 0.01). Pre-administration of the bradykinin B1 antagonist [Leu8]-des-Arg (100 nmol/Kg) blocked the SAR-induced PPE in the tumor area.

Conclusions

Our data suggest that the B1 receptor modulates PPE in the blood tumor barrier of C6 glioma. A possible role for the use of SAR in the chemotherapy of gliomas deserves further study.