Figure 3.

Comparison of anti-Aβ titers of Aβ vaccinated APP and nontransgenic mice after acid dissociation of Aβ and anti-Aβ antibody. Results are from sera obtained 14 days after the fourth vaccination. All samples were incubated at pH 2.5, centrifuged through 10,000 MW filters and neutralized before ELISA assay. So the effects of genotype could be directly compared in the three vaccine conditions, the nontransgenic titer value for each vaccine group was set to 100%. Data presented are mean ± sem. * P < 0.05 compared to APP mice given the same vaccine. Sample size is 5–6 per group.