These confocal images show the projection pattern of a P8 Brn3c null mutant mouse. DiI (red) was inserted into the basal turn, DiA (green) was inserted into the apical turn. Note that the fibers run in discrete bundles inside the cochlear nerve (a), spiral around each other near the root and project to distinct medial and lateral divisions of the ventral cochlear nucleus (b). These data suggest that a crude cochleotopic projection can form independently of any signaling from the immature hair cells of the cochlea. Arrow indicates the efferent bundle as it leaves the afferent fiber tract. Bar indicates 100 μm.
Xiang et al. BMC Neuroscience 2003 4:2 doi:10.1186/1471-2202-4-2