Table 3

Average morphometric data of the renal nerves’ myelinated and unmyelinated fibers, from the six experimental groups: acute diabetic group (15 days after STZ injection), acute treated group, acute control group, chronic diabetic group (12 weeks after STZ injection), chronic treated group and chronic control group
Acute diabetic Acute treated Acute control Chronic diabetic Chronic treated Chronic control
Myelinated fiber area (μm2) 14.2 ± 1.5 11.8 ± 0.8 20.8 ± 2.8° 17.8 ± 1.6° 19.6 ± 2.3° 11.1 ± 1.0
Myelinated fiber diameter (μm) 3.9 ± 0.1 3.7 ± 0.1 4.7 ± 0.3° 4.3 ± 0.2° 4.4 ± 0.3° 3.3 ± 0.1
G ratio 0.56 ± 0.01 0.55 ± 0.01 0.54 ± 0.01 0.56 ± 0.01° 0.55 ± 0.01 0.53 ± 0.01
Myelin sheath area (μm2) 8.9 ± 0.9 7.9 ± 0.51 13.9 ± 1.7+° 11.3 ± 0.9° 12.1 ± 1.3° 7.7 ± 0.6
Myelinated axon area (μm2) 5.2 ± 0.7 3.9 ± 0.4 6.9 ± 1.2° 6.4 ± 0.7° 7.5 ± 1.1° 3.5 ± 0.4
Myelinated axon diameter (μm) 2.3 ± 0.2 2.1 ± 0.1 2.6 ± 0.2° 2.5 ± 0.1° 2.5 ± 0.2° 1.8 ± 0.1
Unmyelinated axon area (μm2) 0.65 ± 0.07 0.62 ± 0.07 0.58 ± 0.03 0.57 ± 0.03 0.80 ± 0.10°# 0.56 ± 0.06
Unmyelinated axon diameter (μm) 0.76 ± 0.04 0.73 ± 0.03 0.73 ± 0.02 0.72 ± 0.02 0.83 ± 0.04° 0.68 ± 0.04

+Indicates difference compared to acute treated, °indicates difference compared to chronic control, #indicates difference compared to chronic diabetic group.

Sato et al.

Sato et al. BMC Neuroscience 2014 15:5   doi:10.1186/1471-2202-15-5

Open Data