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proNGF/NGF mixtures induce gene expression changes in PC12 cells that neither singly produces

Ivan Arisi1, Mara D’Onofrio12, Rossella Brandi1, Francesca Malerba35, Francesca Paoletti3, Andrea Ennio Storti1, Fulvio Florenzano4, Luisa Fasulo3 and Antonino Cattaneo35*

Author Affiliations

1 Genomics Facility, European Brain Research Institute (EBRI) “Rita Levi-Montalcini”, Via del Fosso di Fiorano, 64, 00143 Roma, Italy

2 Istituto di Farmacologia Traslazionale, CNR, Via del Fosso del Cavaliere 100, 00133 Roma, Italy

3 Neurotrophic Factors and Neurodegenerative Diseases Laboratory, European Brain Research Institute (EBRI) “Rita Levi-Montalcini”, Via del Fosso di Fiorano, 64, 00143 Roma, Italy

4 European Brain Research Institute (EBRI) “Rita Levi-Montalcini”, Confocal Microscopy Unit, Via del Fosso di Fiorano, 64, 00143 Roma, Italy

5 Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy

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BMC Neuroscience 2014, 15:48  doi:10.1186/1471-2202-15-48

Published: 8 April 2014

Additional files

Additional file 1:

Log2 Fold Change ratios for the analysed selected genes. Table of Log2 Fold Change ratio for the analysed 65 selected genes, at 5, 15, 30, 60 minutes, with the three treatments, where proNGF/NGF = P/N in ng/ml: NGF-only with P/N = 0/10, proNGF-only with P/N = 20/0 or P/N = 200/0. The 36 genes with a stronger proNGF-mediated effect at 30 minutes are highlighted in light blue. Colour scale corresponds to Fold Change values.

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