Oxygen consumption rates (OCR) in isolated single muscle fibers. (A) Average OCR (pMoles/min) in single muscle fibers isolated from flexor digitorum brevis (FDBs) of App(swe)/PS1(ΔE9) (DTG) and non-transgenic (NTG) male mice (3 mo). Solid black line (NTG) and dotted line (DTG). (B) Graphical presentation of traces in (A). Black bars (NTG) and white bars (DTG). Data are presented as the average OCR ± SE. N = 3-5 separate animals per genotype. *p < 0.01. Arrows represent successive additions of oligomycin (1 μg/ml), FCCP + pyruvate (400 nM + 10 mM respectively), and antimycin A (1 μM).
Schuh et al. BMC Neuroscience 2014 15:24 doi:10.1186/1471-2202-15-24