Table 1

Patient characteristics
  Patient 1 Patient 2 Patient 3
1st surgery 2nd surgery 1st surgery 2nd surgery 1st surgery 2nd surgery
Age (years) 47 48 29 30 51 52
Gender Male Female Female
Years of education 10 10 19
Tumor entity glioblastoma WHO grade IV glioblastoma WHO grade IV astrocytoma WHO grade III astrocytoma WHO grade III glioblastoma WHO grade IV glioblastoma WHO grade IV
Tumor location opIFG opIFG anG anG opIFG opIFG
Tumor volume (cm3) 20.6 21.7 65.5 6.7 195.4 45.3
Time between surgeries (months) 7 15 10
Adjuvant therapy before surgery none RTx & TMZ none TMZ none RTx & TMZ
Correct baseline pictures (out of 131) 104 (79%) 102 (78%) 101 (77%) 98 (75%) 81 (62%) 98 (75%)
RMT (% output) 30 30 34 35 28 33
Mapping intensity (% of MT) 110 100 100 100 100 100
Most comfortable frequency 5 Hz/5 7 Hz/5 5 Hz/5 5 Hz/5 5 Hz/5 7 Hz/7
Pain during stimulation (VAS): convexity 3 4 2 4 1 7
Pain during stimulation (VAS): temporal 6 7 7 6 4 7
Number of errors left hemisphere 119 62 151 135 151 83
Number of stimulations left hemisphere 750 390 675 405 641 258
Error rate left hemisphere 15.9% 15.9% 22.4% 33.3% 23.6% 32.2%
no response 3.3% 6.2% 13.3% 8.6% 2.8% 8.9%
performance 2.5% 1.3% 2.5% 7.4% 8.6% 9.3%
hesitation 9.7% 7.4% 5.6% 16.0% 9.5% 13.6%
neologism 0.3% 0.0% 0.7% 0.7% 2.7% 0.0%
phonological error 0.0% 0.5% 0.0% 0.0% 0.0% 0.0%
semantic error 0.0% 0.5% 0.1% 0.5% 0.0% 0.4%
Preoperative aphasia 0 0 0 1A 1A 2A
Postoperative aphasia (5th day after surgery) 0 0 1B 1A 2A 2A
Postoperative aphasia (3 months after surgery) 0 0 0 1A 0 2A
Extent of tumor resection Complete Complete Complete Complete Complete Partial

This table shows the characteristics of all patients including pre- and intraoperative findings. Aphasia scale: 0 (no aphasia), 1 (mild aphasia with unremarkable communication), 2 (slightly impaired communication), 3 points (severe grade of aphasia); motoric aphasia = A, sensory aphasia = B. Moreover, the extent of tumor resection is presented. RMT = resting motor threshold (% stimulator output), VAS = visual analogue scale, RTx = radiotherapy, TMZ = Temozolomide.

Krieg et al.

Krieg et al. BMC Neuroscience 2014 15:20   doi:10.1186/1471-2202-15-20

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