Table 2

The five strongest positive and negative correlations of each receptor with other receptors, calculated using 169 brain regions
1) mGluR1 2) mGluR2 3) mGluR3 4) mGluR4 5) mGluR5 6) mGluR6
50 0.80 72 0.65 90 0.72 57 0.93 72 0.82 88 0.63
4 0.74 18 0.64 43 0.62 50 0.76 39 0.81 4 0.63
57 0.71 43 0.63 23 0.51 1 0.74 65 0.80 57 0.60
46 0.65 97 0.60 22 0.50 46 0.68 7 0.79 50 0.54
98 0.63 23 0.58 93 0.49 47 0.66 43 0.76 47 0.53
68 −0.51 69 −0.33 6 −0.22 62 −0.64 50 −0.32 42 −0.34
52 −0.53 80 −0.34 59 −0.26 39 −0.64 46 −0.39 39 −0.35
75 −0.54 46 −0.35 69 −0.27 76 −0.68 47 −0.49 32 −0.39
40 −0.55 57 −0.55 57 −0.31 30 −0.72 57 −0.57 22 −0.42
32 −0.63 4 −0.56 4 −0.32 42 −0.76 4 −0.58 23 −0.50
7) mGluR7 8) mGluR8 9) GABA1 10) GABA2 11) D1 12) D2
5 0.79 15 0.57 10 0.63 9 0.63 65 0.74 40 0.71
72 0.76 74 0.52 92 0.57 49 0.58 21 0.74 35 0.69
62 0.65 53 0.47 1 0.49 17 0.58 22 0.71 68 0.67
65 0.65 40 0.47 98 0.49 39 0.56 43 0.70 75 0.66
42 0.64 38 0.46 50 0.47 34 0.56 33 0.69 100 0.66
50 −0.40 50 −0.34 8 −0.25 54 −0.27 4 −0.31 50 −0.49
57 −0.50 4 −0.35 32 −0.25 27 −0.28 47 −0.32 77 −0.50
46 −0.50 98 −0.39 41 −0.28 12 −0.31 69 −0.32 46 −0.60
4 −0.52 1 −0.39 14 −0.31 83 −0.32 57 −0.34 85 −0.67
47 −0.59 57 −0.43 53 −0.31 32 −0.41 54 −0.35 49 −0.70
13) D3 14) D4 15) D5 16) α1A 17) α1B 18) α1D
91 0.68 51 0.40 72 0.66 84 0.52 56 0.63 72 0.76
27 0.65 70 0.22 75 0.63 63 0.38 39 0.63 36 0.72
33 0.64 98 0.18 68 0.62 7 0.31 30 0.63 5 0.71
21 0.63 97 0.17 52 0.61 94 0.26 42 0.59 2 0.64
12 0.62 46 0.17 82 0.60 79 0.26 55 0.59 39 0.64
34 −0.19 7 −0.29 1 −0.47 39 −0.14 35 −0.29 47 −0.39
10 −0.22 9 −0.31 46 −0.49 74 −0.16 57 −0.30 80 −0.43
49 −0.24 94 −0.31 50 −0.50 90 −0.18 54 −0.30 46 −0.45
46 −0.27 68 −0.34 57 −0.60 20 −0.22 64 −0.30 4 −0.53
50 −0.30 60 −0.35 4 −0.60 44 −0.31 4 −0.35 57 −0.54
19) α2A 20) α2B 21) α2C 22) β1 23) β2 24) β3
73 0.63 91 0.50 11 0.74 29 0.74 93 0.68 78 0.69
81 0.50 13 0.43 33 0.67 11 0.71 100 0.62 79 0.67
83 0.49 12 0.42 91 0.65 39 0.71 68 0.60 100 0.63
7 0.48 35 0.40 27 0.65 37 0.69 97 0.59 82 0.61
52 0.47 43 0.33 13 0.63 56 0.69 40 0.58 89 0.57
91 −0.27 80 −0.24 57 −0.25 47 −0.44 6 −0.50 77 −0.19
4 −0.27 49 −0.27 47 −0.26 54 −0.44 85 −0.53 98 −0.20
47 −0.29 25 −0.31 1 −0.29 69 −0.45 34 −0.56 56 −0.22
50 −0.30 34 −0.32 46 −0.32 57 −0.50 4 −0.57 85 −0.30
46 −0.33 77 −0.33 50 −0.34 4 −0.53 57 −0.59 49 −0.31
25) 5-HT1A 26) 5-HT1B 27) 5-HT1D 28) 5-HT1E 29) 5-HT1F 30) 5-HT2A
39 0.66 40 0.67 21 0.65 65 0.62 56 0.87 42 0.84
62 0.64 100 0.61 13 0.65 5 0.58 30 0.83 29 0.83
42 0.64 82 0.61 94 0.63 62 0.56 86 0.80 39 0.80
30 0.64 78 0.61 40 0.60 39 0.55 55 0.78 55 0.80
7 0.62 35 0.60 33 0.59 43 0.53 39 0.78 56 0.76
20 −0.31 1 −0.30 49 −0.30 14 −0.17 66 −0.35 54 −0.40
47 −0.35 98 −0.32 98 −0.32 95 −0.19 69 −0.39 1 −0.43
54 −0.35 49 −0.38 1 −0.32 57 −0.24 57 −0.46 47 −0.54
57 −0.49 85 −0.39 46 −0.44 4 −0.25 54 −0.48 57 −0.71
4 −0.51 46 −0.46 50 −0.46 54 −0.30 4 −0.49 4 −0.72
31) 5-HT2B 32) 5-HT2C 33) 5-HT4 34) 5-HT5A 35) 5-HT6 36) 5-HT7
61 0.54 75 0.70 65 0.79 85 0.63 12 0.69 18 0.72
35 0.54 68 0.64 5 0.71 49 0.63 40 0.65 72 0.72
45 0.53 94 0.63 11 0.69 77 0.59 100 0.63 38 0.65
58 0.51 12 0.61 21 0.67 1 0.56 26 0.60 7 0.60
88 0.48 40 0.60 62 0.67 10 0.56 27 0.56 68 0.59
62 −0.16 85 −0.61 46 −0.45 40 −0.44 46 −0.33 57 −0.46
17 −0.18 1 −0.63 57 −0.48 78 −0.47 77 −0.35 80 −0.47
49 −0.21 98 −0.64 50 −0.49 95 −0.47 56 −0.39 49 −0.49
85 −0.21 46 −0.70 4 −0.50 100 −0.54 85 −0.50 85 −0.61
56 −0.24 50 −0.76 47 −0.50 23 −0.56 49 −0.54 46 −0.62
37) M1 38) M2 39) M3 40) M4 41) M5 42) H1
43 0.73 36 0.65 5 0.81 12 0.71 75 0.80 30 0.84
39 0.70 72 0.63 30 0.80 100 0.70 53 0.65 39 0.80
22 0.69 15 0.59 42 0.80 68 0.69 68 0.63 62 0.77
29 0.67 26 0.57 43 0.78 75 0.68 82 0.61 55 0.74
56 0.65 53 0.53 29 0.78 26 0.67 83 0.59 5 0.73
59 −0.36 46 −0.45 69 −0.40 49 −0.53 1 −0.47 50 −0.43
44 −0.37 99 −0.45 54 −0.44 1 −0.55 46 −0.52 1 −0.45
57 −0.45 80 −0.46 47 −0.44 85 −0.58 50 −0.53 47 −0.54
4 −0.45 77 −0.50 57 −0.62 50 −0.58 49 −0.60 57 −0.72
69 −0.55 85 −0.53 4 −0.64 46 −0.64 85 −0.69 4 −0.76
43) H2 44) H3 45) H4 46) B1 47) B2 48) CCK1
39 0.78 69 0.42 58 0.56 50 0.78 46 0.76 67 0.67
5 0.76 12 0.39 89 0.54 47 0.76 4 0.66 75 0.53
72 0.73 9 0.39 35 0.53 85 0.70 57 0.63 41 0.52
37 0.73 4 0.36 31 0.53 4 0.68 50 0.61 53 0.49
11 0.70 20 0.29 61 0.52 57 0.66 6 0.53 58 0.46
80 −0.30 16 −0.31 86 −0.19 36 −0.62 62 −0.50 46 −0.26
47 −0.35 29 −0.32 98 −0.24 40 −0.64 52 −0.52 50 −0.33
69 −0.42 55 −0.33 56 −0.24 75 −0.69 30 −0.54 85 −0.34
4 −0.50 37 −0.37 85 −0.30 68 −0.69 42 −0.54 49 −0.35
57 −0.50 97 −0.38 49 −0.31 32 −0.70 7 −0.59 98 −0.38
49) CCK2 50) CRF1 51) CRF2 52) Gal1 53) Gal2 54) Gal3
85 0.93 1 0.80 14 0.40 15 0.61 75 0.75 64 0.62
56 0.78 46 0.78 85 0.39 68 0.61 73 0.67 78 0.56
77 0.71 4 0.76 86 0.34 60 0.59 41 0.65 100 0.56
98 0.67 57 0.74 49 0.31 73 0.57 83 0.64 24 0.55
46 0.63 98 0.71 22 0.30 32 0.57 82 0.63 89 0.55
41 −0.60 40 −0.58 94 −0.29 57 −0.52 50 −0.48 39 −0.44
75 −0.67 94 −0.61 36 −0.29 1 −0.53 46 −0.49 85 −0.44
100 −0.69 68 −0.66 75 −0.33 50 −0.56 49 −0.58 29 −0.48
12 −0.70 75 −0.68 41 −0.34 46 −0.56 98 −0.59 49 −0.54
66 −0.71 32 −0.76 68 −0.41 4 −0.58 85 −0.63 56 −0.63
55) MCH1 56) MCH2 57) MC1 58) MC2 59) MC3 60) MC4
30 0.80 29 0.87 4 0.93 45 0.56 60 0.34 52 0.59
29 0.78 49 0.78 50 0.74 35 0.54 69 0.29 32 0.56
42 0.74 30 0.76 1 0.71 61 0.53 44 0.27 68 0.56
39 0.72 39 0.75 46 0.66 31 0.51 41 0.26 75 0.55
56 0.71 86 0.74 47 0.63 100 0.47 84 0.24 15 0.47
47 −0.29 12 −0.43 15 −0.60 86 −0.18 2 −0.24 98 −0.38
44 −0.33 100 −0.44 39 −0.62 56 −0.21 23 −0.24 1 −0.40
69 −0.36 64 −0.46 76 −0.65 85 −0.25 90 −0.25 47 −0.44
57 −0.50 66 −0.55 30 −0.71 98 −0.25 3 −0.26 50 −0.45
4 −0.52 54 −0.63 42 −0.72 49 −0.25 37 −0.36 46 −0.54
61) MC5 62) Y1 63) Y2 64) Y4 65) Y5 66) Y6
88 0.55 65 0.93 7 0.59 54 0.62 62 0.93 100 0.66
31 0.54 42 0.77 42 0.53 100 0.59 5 0.80 75 0.63
58 0.53 5 0.73 62 0.51 96 0.57 33 0.79 12 0.61
45 0.52 39 0.70 65 0.50 89 0.57 11 0.74 82 0.58
6 0.51 33 0.67 30 0.45 24 0.55 39 0.73 36 0.57
11 −0.12 46 −0.39 46 −0.34 85 −0.33 46 −0.38 46 −0.45
90 −0.14 50 −0.43 57 −0.40 30 −0.36 50 −0.44 77 −0.51
98 −0.14 47 −0.50 50 −0.41 49 −0.39 47 −0.49 56 −0.55
91 −0.14 57 −0.57 47 −0.47 86 −0.40 57 −0.54 85 −0.70
22 −0.16 4 −0.64 4 −0.51 56 −0.46 4 −0.59 49 −0.71
67) NT1 68) NT2 69) μ 70) δ 71) κ 72) ORL-1
48 0.67 75 0.81 4 0.49 43 0.61 72 0.52 5 0.82
75 0.65 94 0.77 57 0.44 22 0.60 62 0.51 7 0.76
68 0.64 40 0.69 44 0.42 37 0.59 65 0.48 18 0.76
82 0.57 12 0.67 1 0.39 56 0.58 5 0.46 39 0.74
41 0.56 32 0.64 9 0.39 90 0.57 17 0.45 43 0.73
85 −0.40 57 −0.56 42 −0.40 66 −0.25 50 −0.13 80 −0.40
50 −0.46 4 −0.57 39 −0.40 83 −0.27 46 −0.18 47 −0.47
46 −0.48 85 −0.61 43 −0.42 53 −0.28 4 −0.18 46 −0.53
57 −0.48 50 −0.66 22 −0.45 4 −0.28 57 −0.19 57 −0.58
4 −0.49 46 −0.69 37 −0.55 69 −0.39 14 −0.19 4 −0.60
73) OX1 74) OX2 75) OT 76) SST1 77) SST2 78) SST3
83 0.69 53 0.54 68 0.81 42 0.72 99 0.77 100 0.78
53 0.67 41 0.53 41 0.80 62 0.66 49 0.71 82 0.73
75 0.64 8 0.52 53 0.75 39 0.64 85 0.70 24 0.69
19 0.63 73 0.50 82 0.72 30 0.62 34 0.59 79 0.66
41 0.57 38 0.48 32 0.70 65 0.61 80 0.57 40 0.66
1 −0.39 92 −0.35 98 −0.59 1 −0.41 12 −0.50 34 −0.47
85 −0.45 50 −0.36 49 −0.67 46 −0.43 93 −0.50 77 −0.49
46 −0.48 77 −0.39 50 −0.68 50 −0.46 66 −0.51 46 −0.49
50 −0.51 98 −0.41 46 −0.69 57 −0.65 95 −0.53 49 −0.53
98 −0.53 85 −0.43 85 −0.73 4 −0.68 100 −0.54 85 −0.59
79) SST4 80) SST5 81) NK1 82) NK2 83) NK3 84) TRHR
24 0.67 50 0.61 40 0.66 100 0.77 73 0.69 16 0.52
78 0.66 85 0.59 27 0.59 78 0.73 53 0.64 67 0.51
100 0.60 46 0.58 94 0.57 75 0.72 75 0.64 32 0.51
82 0.58 77 0.57 12 0.57 40 0.65 82 0.64 75 0.51
2 0.54 4 0.56 82 0.57 83 0.64 41 0.59 83 0.50
77 −0.17 18 −0.43 4 −0.36 4 −0.42 49 −0.54 49 −0.38
57 −0.18 23 −0.44 57 −0.36 50 −0.44 46 −0.54 50 −0.38
4 −0.20 38 −0.46 1 −0.40 49 −0.54 50 −0.55 85 −0.38
49 −0.25 75 −0.46 50 −0.46 46 −0.59 85 −0.57 98 −0.40
85 −0.29 36 −0.47 46 −0.49 85 −0.63 98 −0.58 46 −0.43
85) VPAC1 86) VPAC2 87) V1a 88) V1b 89) V2 90) A1
49 0.93 29 0.80 76 0.46 6 0.63 100 0.65 3 0.72
77 0.70 56 0.74 19 0.44 61 0.55 78 0.63 98 0.59
46 0.70 30 0.67 7 0.40 31 0.48 24 0.57 70 0.57
98 0.68 55 0.62 32 0.40 58 0.43 64 0.57 43 0.53
50 0.65 22 0.62 52 0.39 96 0.38 54 0.55 39 0.53
12 −0.67 66 −0.35 50 −0.32 30 −0.22 98 −0.34 84 −0.34
41 −0.69 4 −0.36 46 −0.33 39 −0.23 77 −0.37 53 −0.34
66 −0.70 69 −0.38 57 −0.36 62 −0.25 56 −0.39 73 −0.34
75 −0.73 64 −0.40 4 −0.36 22 −0.26 85 −0.47 32 −0.36
100 −0.74 54 −0.42 47 −0.39 23 −0.26 49 −0.50 83 −0.39
91) A2A 92) A2B 93) A3 94) P2Y1 95) P2Y2 96) P2Y4
13 0.68 9 0.57 23 0.68 68 0.77 100 0.58 64 0.57
21 0.65 99 0.51 100 0.59 32 0.63 23 0.55 24 0.52
11 0.55 22 0.46 41 0.57 27 0.63 40 0.54 79 0.47
27 0.53 56 0.45 97 0.56 21 0.58 12 0.49 89 0.44
12 0.53 49 0.44 78 0.55 81 0.57 38 0.49 54 0.43
10 −0.25 53 −0.28 99 −0.37 57 −0.45 99 −0.46 86 −0.17
55 −0.25 100 −0.31 34 −0.43 4 −0.46 34 −0.47 62 −0.18
87 −0.25 66 −0.34 49 −0.48 1 −0.48 77 −0.53 42 −0.18
19 −0.27 54 −0.34 77 −0.50 46 −0.55 49 −0.54 30 −0.19
76 −0.29 74 −0.35 85 −0.53 50 −0.61 85 −0.54 87 −0.23
97) P2Y6 98) P2Y11 99) CB1 100) CB2
2 0.60 50 0.71 77 0.77 78 0.78
23 0.59 85 0.68 49 0.54 82 0.77
93 0.56 49 0.67 85 0.53 40 0.70
15 0.49 46 0.64 92 0.51 12 0.66
3 0.48 1 0.63 80 0.46 66 0.66
1 −0.31 73 −0.53 93 −0.37 46 −0.49
80 −0.36 83 −0.58 23 −0.38 34 −0.54
44 −0.38 75 −0.59 100 −0.38 77 −0.54
57 −0.45 53 −0.59 38 −0.45 49 −0.69
4 −0.50 32 −0.64 95 −0.46 85 −0.74

The receptor numbers (Table 1) are given in the left column and the correlations in the right column (e.g., mGluR1 has the strongest positive correlation with CRF1 (0.80)). Correlations with an absolute value of less than 0.34 are not significant after the Bonferroni correction (at α = 0.05) and should be interpreted with caution. The actual correlations may be somewhat stronger due the imperfect reliability of the expression data (the statistical “attenuation” phenomenon).

For compactness, the following abbreviations were used: GABA1 = GABABR1, GABA2 = GABABR2.

Janušonis

Janušonis BMC Neuroscience 2014 15:16   doi:10.1186/1471-2202-15-16

Open Data