B355252 inhibits glutamate-induced accumulation of intracellular Ca2+. HT-22 was exposed to glutamate alone and in the presence of B355252. Changes in intracellular Ca2+ load was measured with the calcium binding dye Fura-2. Accumulation in Ca2+ by glutamate treatment was significantly attenuated by 8 μM of B355252. B355252 alone did not alter Ca2+ homeostasis in the cell. (***p<0.001 compared to glutamate-treated cells; ###p<0.001 compared to control).
Gliyazova et al. BMC Neuroscience 2013 14:93 doi:10.1186/1471-2202-14-93