Longitudinal expression of disease-associated mRNAs from HD monkeys. The longitudinal trends for selected disease-associated mRNAs from the HD monkeys, with parallel dysregulation in human HD blood, are plotted in panels A-K. All data represent raw fluorescence units (log transformed) from the rhesus Affymetrix profiling results of white blood samples collected from 5, 11, 17, and 23 months for each of the 4 control and 4 HD monkeys. The fluorescence values for all 4 controls were analyzed together and the values for all 4 HD monkeys were analyzed together; one blood sample was analyzed per monkey per timepoint. All mRNA candidates have a disease-association P value of < 0.05 by 2-way ANOVA. A table of stats, including P values and FDRs for disease-association and age-effect by Two-Way ANOVA are outlined in panel L.
Kocerha et al. BMC Neuroscience 2013 14:88 doi:10.1186/1471-2202-14-88